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Mechanics of Biological Systems and Materials, Volume 5: Proceedings of the 2012 Annual Conference on Experimental and Applied Mechanics, the fifth volume of seven from the Conference, brings together 31 contributions to this important area of research and engineering. The collection presents early findings and case studies on fundamental and applied aspects of Experimental and Applied Mechanics, including papers on: §Biological Materials & MechanicsCell MechanicsMechanics of Biomimetic MaterialsMechanics of Brain Tissues and StructuresMechanics of Bone and Related MaterialsMulti-Scale Mechanics of Natural FibersIndentation Methods in Soft MaterialsImaging Methods in Biological Systems and MaterialsMechanics of Tissue DamageMechanics of Soft Materials and Tissues