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Precision Medicine in Neurodegenerative Disorders, Part I is in the midst of a major transformation, fueled by the recognition that what has worked for developing symptomatic therapies will not work for developing disease modifying therapies. The former depends on addressing convergent, common denominators of disease, present in most of those affected; the latter on divergent biological signals, present in some but absent in most. Why and How we are reconfiguring the warfare in disease modification after four decades of trying will be the subject of this volume. The topic encompasses two volumes separated into multiple sections: conceptual frameworks, pitfalls in definitions, cohorts, and measures of progression, basic science development, and clinical trials and therapeutic approaches. Summarizes theory and research on precision medicine in neurodegenerative disorders Covers basic biology to clinical trials and therapeutics Includes disease mechanisms, genetic subtypes, and more
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