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Neuroprosthetics has been an area of intense interest and continued progress since the introduction of the cardiac pacemaker in 1932. Subsequently, we witnessed the development of cochlear prostheses, techniques for bladder and bowel control, deep brain stimulation, and methods of restoring mobility to paralyzed individuals. This text is designed for graduate students, clinicians and researchers in neuroprosthetics. It is broadly divided into three sections: Section 1 provides pertinent background information on neuroanatomy and neurophysiology, biomaterials and biocompatibility, stimulation and recording techniques; Section 2 describes current clinical applications of neuroprosthetics; and Section 3 focuses on future developments in the field.