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Więcej informacji o Gamma-Glutamyl Transpeptidases

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Opis

Gamma-Glutamyl Transpeptidases ( -GTs) are members of the N-terminal nucleophile hydrolase superfamily, enzymes that cleave the -glutamyl amide bond of glutathione to liberate cysteinylglycine. The released -glutamyl group can be transferred to water (hydrolysis) or to amino acids or short peptides (transpeptidation). -GT plays a key role in the gamma glutamyl cycle by regulating the cellular levels of the antioxidant glutathione, hence it is a critical enzyme in maintaining cellular redox homeostasis. -GT is upregulated during inflammation and in several human tumors, and it is involved in many physiological disorders related to oxidative stress, such as Parkinson s disease and diabetes. Furthermore, this enzyme is used as a marker of liver disease and cancer. This book covers current knowledge about the structure-function relationship of -GTs and gives information about applications of -GTs in different fields ranging from clinical biochemistry to biotechnology and biomedicine.

Szczegóły książki

Kategoria Książki po angielsku Mathematics & science Biology, life sciences Biochemistry

• Pełny tytuł: Gamma-Glutamyl Transpeptidases
• Podtytuł: Structure and Function
• Autor: Immacolata Castellano, Antonello Merlino
• Język: Angielski
• Oprawa: Miękka
• Liczba stron: 57
• EAN: 9783034806817
• ISBN: 3034806817
• ID: 01439009
• Wydawca: Springer Basel
• Waga: 1182 g
• Wymiary: 235 × 155 × 6 mm
• Data wydania: 10. July 2013

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