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Więcej informacji o Studies On the Coxsackie and Adenovirus Receptor

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Opis

CAR has recently been identified as a high affinity §receptor for both Coxsackievirus and certain §adenovirus (AV) serotypes. Virus bound by CAR is §passed to integrins which bind an RGD (Arg-Gly-Asp) §sequence in the viral penton base protein and act as §secondary receptors responsible for virus §internalization.§§Recent studies have shown that, in integrin-§expressing cells, CAR can directly mediate AV uptake §without penton base RGD-av integrin interactions. I §confirmed that EC+ transmembrane (TM) domains of CAR §are sufficient for AV uptake in integrin-expressing §cells.§§CAR is the primary AV receptor and integrins are §secondary AV receptors. To investigated the §possibility that these proteins associate in a §functional complex in the cell membrane, I forced §CAR expression in a line of human myoblasts and §obtained coprecipitation of CAR and B3 integrin §suggesting these proteins may associate.§§I also found that mouse brain extract reproducibly §modifies the immunoreactivity of the CAR C-terminal §fusion protein and increase its tendency to §dimerize. Mouse brain extracts also modified the §isoelectric pH of the CAR C-terminal fusion protein.

Szczegóły książki

• Pełny tytuł: Studies On the Coxsackie and Adenovirus Receptor
• Podtytuł: Functional Studies On the Coxsackie and Adenovirus Receptor (CAR) in Skeletal Muscle Cells
• Autor: Yunlin Tai
• Język: Angielski
• Oprawa: Miękka
• Liczba stron: 88
• EAN: 9783639151831
• ID: 06823710
• Wydawca: VDM Verlag Dr. Müller
• Waga: 147 g
• Wymiary: 220 × 150 × 5 mm
• Rok wydania: 2009

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