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Więcej informacji o Synthesis of Tetrahydropyran/ tetrahydrofuran derivatives

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Opis

In this book, a metal-free protocol for the synthesis of 2, 3, 6-trisubstituted tetrahydropyrans using molecular iodine under mild conditions; Prins/Ene cyclisation and Prins/Ene bicyclization process for the stereoselective synthesis of a novel series of spiropyrolidine derivatives; a novel bicyclization strategy for the synthesis of indeno [2,1-c]pyran and cyclopenta[c]pyran scaffolds from aldehydes and exo-olefinic diols and a novel one-pot strategy has been developed for the synthesis of 3',4,4',5-tetrahydro-2H,2'H-spiro[furan-3,1'-naphthalen]-2'-one scaffolds through a pinacol 1,2-shift terminated Prins cyclization explained very efficiently. In contrast with the rapidly growing interest in such reactions, little effort has been focused on construction of O-containing heterocyclic scaffolds.These processes would be extremely useful for obtaining O- Heterocycles which comprises around 60% of all drug substances. Though few reports are there, still exploration in this field is highly desirable. These observations led us to choose Prins type cascade cyclizations as a key topic for our research.

Szczegóły książki

• Pełny tytuł: Synthesis of Tetrahydropyran/ tetrahydrofuran derivatives
• Autor: Boggu Jagan Mohan Reddy, N. Prudhvi Raju
• Język: Angielski
• Oprawa: Miękka
• Liczba stron: 120
• EAN: 9786202095914
• ID: 18902979
• Wydawca: LAP Lambert Academic Publishing
• Waga: 197 g
• Wymiary: 220 × 150 × 7 mm
• Rok wydania: 2018

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