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Więcej informacji o Synthesis, structure & bioactivity of organotin(IV)hydrazone compounds

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Opis

The reaction of pyruvic acid phenylhydrazone [HPAPD, (1)] with organotin(IV) chloride(s) yielded the organotin(IV) complexes (2-11). Molecular structural assessments of the complexes (2-11) have been based on data from UV-Vis, IR, 1H and 13C NMR spectral studies. The molecular structure of HPAPD (1) has also been determined by X-ray diffraction. Spectroscopic data suggested that HPAPD (1) is coordinated to the tin(IV) atom via carboxylate-O and azomethine-N atoms and acted as a mononegative bidentate chelating agent in all the organotin(IV) complexes (2-11). Spectral data indicated that thiocyanate group is N-coordinated to the Sn(IV) ion in the complexes (7-9). The coordination number of tin in all the organotin(IV) complexes (2-11) is five. The cytotoxicity of the compounds 1-11 was studied against Artemia salina. The free ligand (1) and its organotin(IV) complexes (2-11) were assayed for in vitro antibacterial activity against Staphylococcus aureus, Bacillus subtilis, Enterobacter aerogenese, Escherichia coli and Salmonella typhi. The biological studies showed that all organotin(IV) complexes (2-11) are more potent antibacterial and cytotoxic agents than their free ligand (1).

Szczegóły książki

• Pełny tytuł: Synthesis, structure & bioactivity of organotin(IV)hydrazone compounds
• Podtytuł: Synthesis and biological studies of organotin(IV) complexes of pyruvic acid phenylhydrazone with thiocyanate co-ligand
• Autor: ffan, alam
• Język: Angielski
• Oprawa: Miękka
• Liczba stron: 76
• EAN: 9783848405695
• ID: 06855679
• Wydawca: LAP Lambert Academic Publishing
• Waga: 130 g
• Wymiary: 220 × 150 × 5 mm
• Rok wydania: 2012

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