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Opis

Na + -K + ATPase or Na-pump ATPase, a member of "P"-type ATPase superfamily, is characterized by association of multiple isoforms mainly of it's - and - subunits. At present four different - ( -1, -2, -3 and -4) and three - ( -1, -2, and -3) isoforms have been identified in mammalian cells and their differential expressions are tissue specific. Regulation of Na + -K + ATPase activity is an important but a complex process, which involves short-term and long-term mechanisms. Short-term regulation of Na + -K + ATPase is either mediated by changes in intracellular Na + concentrations that directly affect the Na + -pump activity or by phosphorylation/dephosphorylation-mediated by some stimulants leading to changes in its expression and transport properties. On the other hand, long-term regulation of Na + -K + ATPase is mediated by hormones, such as mineralocorticoids and thyroid hormones, which cause changes in the transcription of genes of - and - subunits leading to an increased expression in the level of Na + -pump. Several studies have revealed a relatively new type of regulation that involves the association of small, single span membrane proteins with this enzyme. These proteins belong to the FXYD family, the members of which share a common signature sequence encompassing the transmembra§ne domain adjacent to the isoform(s) of - subunits of Na + -K + ATPase. Considering the extraordinary importance of Na + -K + ATPase in cellular function, several internationally established investigators have contributed their articles in the monograph entitled "Regulation of Membrane Na + -K + ATPase" for inspiring young scientists and graduate students to enrich their knowledge on the enzyme, and we are sure that this book will soon be considered as a comprehensive scientific literature in the area of Na + -K + ATPase regulation in health and disease.§§

Szczegóły książki

Kategoria Książki po angielsku Medicine Medicine: general issues Medical equipment & techniques

• Pełny tytuł: Regulation of Membrane Na+-K+ ATPase
• Autor: Sajal Chakraborti, Naranjan S Dhalla
• Język: Angielski
• Oprawa: Twarda
• Liczba stron: 436
• EAN: 9783319247489
• ISBN: 3319247484
• ID: 09523641
• Wydawca: Springer International Publishing AG
• Waga: 7922 g
• Wymiary: 235 × 155 × 32 mm
• Data wydania: 22. December 2015

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