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Opis

There is a need to inform the public that not all generic drugs are manufactured by the same process and that the different processes may have dramatically different environmental impacts. Two global forces are at odds today - the push for "greener" processes and the push for lower drug prices.§This book presents detailed discussions of the published process chemistry of the ten top-selling small molecule drugs in the US in 2007, information which is usually carefully protected by the current and future manufacturers. The author identifies methodology for manufacturing these blockbuster drugs most efficiently and to highlight methodology and strategies which might be used to expedite the manufacturing of the blockbusters of the future.§The content of each chapter reflects the range of tasks assigned to process chemists whose role on a process research and development team may be early route selection in one project or late troubleshooting of a difficult crystallization to produce a target which filters well and meets crystal size and purity specifications in another.Standardizes and expands upon information available in process patents for "blockbuster" drugs§There is a need to inform the public that generic versions of a drug may not be manufactured by the same process as brand-name drugs and that the different processes may have dramatically different environmental impacts. Two global forces are at odds today-the push for "greener" processes and the push for lower drug prices. This book brings this conflict into sharp focus by discussing in detail the published process chemistry for top-selling small molecule drugs.§Providing insights about process route selection, choice of reagents, and reaction conditions, Pharmaceutical Process Chemistry for Synthesis guides process chemists in identifying best processes for manufacturing these blockbuster drugs as they lose patent protection. Further, it highlights the strategies and methodology that might be useful for expediting the process research and development of the blockbusters of the future. Pharmaceutical Process Chemistry for Synthesis also:§Presents detailed discussions of the published process chemistry of Lipitor(r), Advair Diskus(r), Prevacid(r), Singulair(r), Seroquel(r), Effexor XR(r), Lexapro(r), and Actos(r)§Aids in the implementation of green chemistry in pharmaceutical manufacturing by comparing and contrasting known multiple processes to the same target§Summarizes the known process chemistry by discussing the advantages of one selected route for each drug§Reflects the range of tasks assigned to process chemists-i.e., manufacturing route selection, conversion of an intermediate to final target§A multi-level table of contents and comprehensive index of reagents for rapid access to specific information§Written from a refreshingly objective perspective, this book is essential for process chemists who need to devise practical syntheses for increasingly complex drugs in a constantly decreasing time frame.

Szczegóły książki

Kategoria Książki po angielsku Technology, engineering, agriculture Industrial chemistry & manufacturing technologies Industrial chemistry

• Pełny tytuł: Pharmaceutical Process Chemistry for Synthesis - Rethinking the Routes to Scale-Up
• Autor: Peter J. Harrington
• Język: Angielski
• Oprawa: Twarda
• Liczba stron: 376
• EAN: 9780470577554
• ISBN: 047057755X
• ID: 01388531
• Wydawca: John Wiley & Sons Inc
• Waga: 1158 g
• Wymiary: 281 × 221 × 25 mm
• Data wydania: 28. January 2011

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